One Potential Genetic Cause of CVID

In 2005, researches in Boston found that one gene, TACI, may cause 15-20% of all cases of CVID. A National Institutes of Health press release states that this is a dominant gene and those who carry it may have a 50% chance of passing it to their children.

Will My Kids Get CVID?

If you have concerns about whether you will pass CVID to your children, read this great, easy-to-read primer on genetics and CVID inheritance.

 Key Points:

• Only 10-20% of people with CVID have genes that have been identified by researchers as contributing to the condition.
• Most people with CVID probably have multiple genetic defects which contribute to their symptoms and the probability of inheritance in difficult to predict.
• CVID may be related to multiple environmental factors as well.

According to the author, CVID is a “multifactorial” condition that may often involve multiple, interacting genetic and environmental factors. Thus, determining whether CVID will be inherited is very difficult.